OVERVIEW
We are currently seeking a highly motivated Scientist I (Contractor) to join a well-known client’s team in San Diego, CA. This role will support the development of a non-viral cell and gene therapy delivery platform, with a focus on advancing innovative nucleic acid payload technologies.
The Scientist I will play a critical role in designing and evaluating novel mRNA and DNA constructs, leveraging a variety of molecular biology techniques to support early research and development efforts. This is an exciting opportunity to work in a fast-paced, cutting-edge environment, contributing to next-generation therapeutic development.

RESPONSIBILITIES
•    Design and clone expression vectors and IVT donor plasmids to support research programs.
•    Perform DNA and mRNA transfections in mouse and human cell lines.
•    Evaluate nucleic acid expression using qRT-PCR, luciferase reporter assays, and Western blotting.
•    Produce and validate in vitro transcribed (IVT) mRNA constructs.
•    Maintain accurate and detailed records in electronic laboratory notebooks (ELN).
•    Prepare study summaries, data presentations, and supporting documentation.
•    Collaborate with cross-functional teams to support research initiatives and experimental goals.

EXPERIENCE
•    Bachelor’s degree with 5+ years of relevant experience OR Master’s degree with 2+ years of experience in molecular biology, pharmaceutical sciences, or a related field.
•    Demonstrated experience in advanced molecular cloning techniques, including Gibson assembly, Golden Gate cloning, and site-directed mutagenesis.
•    Hands-on experience with in vitro transcription (IVT) and nucleic acid handling.
•    Experience with functional assays such as qRT-PCR and reporter assays to measure gene expression.
•    Experience with cell culture and transfection techniques (mammalian cell lines required; primary cells preferred).
•    Familiarity with tools such as SnapGene, GraphPad Prism, and Microsoft Office is desirable.

EDUCATION
•    Bachelor’s or Master’s degree in Molecular Biology, Pharmaceutical Sciences, or a related scientific discipline required.

TO BE A BEST FIT, YOUR STRENGTHS MUST INCLUDE
•    Strong technical expertise in molecular biology and nucleic acid technologies.
•    Excellent attention to detail and ability to maintain accurate, high-quality documentation.
•    Strong analytical and problem-solving skills.
•    Effective communication skills with the ability to clearly present scientific data.
•    Ability to work both independently and collaboratively in a fast-paced research environment.
•    Strong organizational and time management skills with the ability to prioritize tasks effectively.
•    Commitment to scientific rigor, reproducibility, and continuous improvement.
 

Full-time employees are also eligible for benefits options such as health coverage, life insurance, disability insurance, and 401k benefits.

At Advanced Group, our commitment to diversity and inclusion in every part of our organization is crucial to fulfilling our mission and demonstrating our REAL values. Advanced Group is committed to providing employment opportunities without regard to sex, race, color, age, national origin, religion, gender identity or expression, sexual orientation or sexual preference, pregnancy or maternity, genetic information, marital status, disability, veteran status, or any other basis protected by applicable federal, state or local law.

Advanced Group complies with federal and state disability laws and makes reasonable accommodations for applicants and candidates with disabilities. If a reasonable accommodation is needed to participate in the job application or interview process, please contact [email protected].

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