OVERVIEW
We are currently searching for an outstanding Scientist I to join a well-known client in San Diego, CA. This role will contribute to the development of a cutting-edge targeted delivery platform by designing, preparing, and characterizing ligand conjugates and lipid nanoparticles. The Scientist I will play a critical role in advancing targeted gene therapy delivery systems, collaborating closely with cross-functional teams to support innovative nanotechnology solutions with impact across the organization and broader biopharmaceutical industry.

RESPONSIBILITIES
•    Design, prepare, and characterize ligand conjugates and targeted lipid nanoparticles (LNPs).
•    Execute bioconjugation reactions (e.g., antibodies, peptides) with small molecules or polymers to support targeted delivery systems.
•    Validate and purify bioconjugates using LC TOF and ÄKTA purification systems.
•    Formulate non-targeted and targeted LNPs encapsulating nucleic acids using microfluidic or T junction mixing technologies.
•    Perform surface bioconjugation for targeted LNPs and support analytical assay development (BLI, fluorescence microscopy, ÄKTA).
•    Evaluate ligand and particle stability under various storage and stress conditions.
•    Maintain accurate electronic laboratory notebooks and author SOPs in accordance with internal standards.
•    Communicate data effectively within cross-functional scientific teams.

EXPERIENCE
•    Extensive hands-on experience with bioconjugation chemistries, process optimization, and biomolecular reaction kinetics.
•    Prior experience in Antibody Drug Conjugate (ADC) development is strongly preferred.
•    Proven experience formulating and characterizing lipid nanoparticles using RiboGreen, Dynamic Light Scattering (DLS), and Zeta potential measurements.
•    Demonstrated ability to produce consistent, high-quality experimental results in a fast-paced research environment.

EDUCATION
•    Master’s degree with 2+ years of experience or
•    Bachelor’s degree with 5+ years of experience
in pharmaceutical sciences, bioengineering, chemical engineering, chemistry, or a related scientific discipline.
(Equivalent combinations of education and experience may be considered.)

TO BE A BEST FIT, YOUR STRENGTHS MUST INCLUDE
•    Strong proficiency in bioconjugation techniques and buffer formulation.
•    Exceptional attention to detail with strong organizational skills.
•    Ability to communicate effectively with cross-functional scientific and technical teams.
•    Proficiency in Microsoft Excel required; experience with Prism, JMP, or other analytical software is a plus.
•    Excellent oral and written communication skills with the ability to clearly present complex scientific data.
 

Full-time employees are also eligible for benefits options such as health coverage, life insurance, disability insurance, and 401k benefits.

At Advanced Group, our commitment to diversity and inclusion in every part of our organization is crucial to fulfilling our mission and demonstrating our REAL values. Advanced Group is committed to providing employment opportunities without regard to sex, race, color, age, national origin, religion, gender identity or expression, sexual orientation or sexual preference, pregnancy or maternity, genetic information, marital status, disability, veteran status, or any other basis protected by applicable federal, state or local law.

Advanced Group complies with federal and state disability laws and makes reasonable accommodations for applicants and candidates with disabilities. If a reasonable accommodation is needed to participate in the job application or interview process, please contact [email protected].

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